The changes in the diagnostics and treatment of hepatic veno-occlusive disease in children

HVOD in children

Abstract

Sinusoidal obstruction syndrome (SOS) of the liver or hepatic veno-occlusive disease (HVOD) is a serious, potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). Expert analyses show differences in SOS / VOD of the liver between adult and pediatric patients (incidence, genetic predisposition, prevention, risk factors, clinical course, treatment, survival and mortality). The new criteria for diagnostics and classification of the disease recommended by European society for blood and marrow transplantation (EBMT) are a key factor in the management of HVOD in childhood. These international recommendations support early diagnosis and early defibrotide treatment of the disease.