Trombotické mikroangiopatie v dětském věku

Abstract

Thrombotic microangiopathy (TMA) is a pathological lesion triggered by endothelial injury or dysfunction. TMA occurs in wide range of diseases and is characterized by microangiopathic hemolytic anemia, thrombocytopenia and ischemic organ injury due to thrombosis in microvasculature. In pediatric age, TMA is observed as primary, i.e. congenital form as secondary, acquired form - especially linked to E. coli infection. Understanding of epidemiology, pathophysiology, laboratory and clinical signs and differential diagnosis is crucial for early and on-time specific diagnostic approach of this life-threatening diseases.