Molecular classification of endometrial cancers translated into practice

Abstract

Endometrial cancer is currently diagnosed based on histopathological morphology. According to the classical Bokhman division, we distinguish 2 relatively wide groups of tumors different in pathogenesis. Type I., estrogen-dependent tumors, clinically usually indolent and type II., non-endometroid tumors, clinically aggressive, without dependence on estrogen stimulation. This classification fulfills a didactic purpose, provides easy orientation for epidemiological data, but is not suitable for stratification due to the overlap of clinical, pathological and molecular features. The Cancer Genome Atlas / TCGA / project classifies endometrial tumors into 4 groups based on molecular genetic features. Integration of the histopathological findings along with molecular classification appears to be the best approach for evaluating each individual tumor. This will achieve the ideal stratification of patients for treatment regimens.