Results of treatment of gestational trophoblastic neoplasia in the Slovak Republic in the years 1993-2017
Keywords:
gestational trophoblastic neoplasia, choriocarcinoma, placental site trophoblastic tumour, epithelioid trophoblastic tumour, invasive mole, curability, mortality, reproductive outcomesAbstract
Objective: Gestational trophoblastic neoplasia epidemiology and treatment results in the Slovak Republic in the years 1993 - 2017
Design: retrospective epidemiological national
Setting: Centre for gestational trophoblastic disease in the Slovak Republic, Bratislava
Methods: Retrospective analysis results of gestational trophoblastic neoplasia treatment in the Centre for gestational trophoblastic disease in the Slovak Republic in Bratislava in the years 1993-2017 according to prognostic scoring and staging system FIGO.
Results: The Centre for gestational trophoblastic disease was created in Slovak Republic in the year 1993, after the split of the former Czechoslovakia. Overall of 100 patients with gestational trophoblastic neoplasia were treated in this Centre in the years 1993 - 2017. According to prognostic scoring and staging system FIGO/WHO 74 % patients were low-risk and 26 % of patients were high-risk gestational trophoblastic neoplasia. There were 56 %, 2 %, 32 % and 10 % patients in stage I, II, III, and IV respectively. Total curability rate was 96 % and mortality rate was 4 %. Curability rate 100 % was achieved in stage I - III and all placental site trophoblastic tumours, and 60 % in stage IV. In the years 1993 - 2017 the incidence of choriocarcinoma were 1 in 59,315 pregnancies and 1 in 42,299 deliveries, placental site trophoblastic tumours 1 in 489,348 pregnancies and 1 in 348,965 deliveries, invasive mole 1 in 139,814 pregnancies and 1 in 99,704 deliveries, and persistent gestational trophoblastic neoplasia 1 in 39,947 pregnancies and 1 in 28,487 deliveries. In the Czech Republic in the same period of time there were treated 281 (301) patients with curability rate 98.6 % (98.7 %).
Conclusion: The results of the treatment of gestational trophoblastic neoplasia in the Slovak Republic are comparable with the results achieved by leading centers specializing for the treatment of this disease in Europe and in the world. Early detection and centralisation of treatment are crucial points for successful treatment, as the high curability rate of gestational trophoblastic neoplasia is achieved by effective therapy.
