Relationship between endometriosis and vaspin RS2236242 gene polymorphism

Abstract

Summary: Objective: The aim of this study is to investigate the relationship between endometriosis and the vaspin RS2236242 gene polymorphism. Materials and methods: This prospective cross-sectional case-control study included patients with grade 4 endometriosis and a healthy control group. Vaspin RS2236242 gene polymorphism was evaluated in these study groups. Results: Thirty eight endometriosis individuals and 17 women from the control group in the study. The group of individuals with endometriosis exhibited similar characteristics to the control group in terms of sex, body mass index (BMI), and age (control mean age: 29.6 ± 4.62 years; BMI: 24.02 kg/m²; endometriosis mean age: 30.4 ± 5.01 years; BMI: 23.63 kg/m²). According to the statistical analysis, there was a significant difference in the genotype distribution of the vaspin RS2236242 polymorphism between people with endometriosis and controls (P = 0.027). Also, the AT genotype was more likely to cause endometriosis than the OR: 2.474 (95% Cl 0.668–9.169) genotypewhen we looked at the genotypes‘ relative risk ratio for endometriosis. Significant differences were observed in total AT and TT genotype frequencies between cases and controls (OR = 2.31; 95% CI 0.86–0.92; P = 0.03). AT and TT genotypes were associated with endometriosis risk. Conclusion: A significant association was observed between vaspin RS2274907 A/T polymorphism and the probability of developing endometriosis.