Assisted reproduction in patients with Klinefelter syndrome

Authors

  • Karel Crha Gynekologicko-porodnická klinika Lékařské fakulty Masarykovy univerzity a FN Brno
  • Michal Ješeta FN Brno https://orcid.org/0000-0003-1778-3454
  • Radovan Pilka Porodnicko-gynekologická Klinika, FN a LF UP Olomouc
  • Marek Kašík Urologická klinika Lékařské fakulty Masarykovy univerzity a FN Brno
  • Lenka Mekiňová Gynekologicko-porodnická klinika Lékařské fakulty Masarykovy univerzity a FN Brno
  • Jan Vodička Porodnicko-gynekologická Klinika, FN a LF UP Olomouc
  • Tomáš Crha Gynekologicko-porodnická klinika Lékařské fakulty Masarykovy univerzity a FN Brno

Keywords:

male sterility, Klinefelter syndrom, spermatogenesis, reproduction, aneuploidy, genetic testing

Abstract

Objective: The goal of this article is to present the current knowledge of Klinefelter syndrome and its impact on male reproductive function as well as the current treatment options.

Design:  Review article

Setting: Department of Obstetrics and Gynecology, Faculty of Medicine, Masaryk university and University Hospital Brno, Department of Urology, Faculty of Medicine, Masaryk university and University Hospital Brno , Department of Obstetrics and Gynecology, University Hospital Faculty of Medicine, Palacky University, Olomouc

Methods: PubMed/Medline, WoS and Scopus were searched for articles indexed until November 2021

Text: Klinefelter syndrome is a chromosomal aberration with an additional X chromosome in male. This may adversely affect testicular growth and spermatogenesis, thus resulting in male infertility. Recently, new knowledge have appeared about the treatment of male infertility.

Conclusion: Interdisciplinary approach enables early diagnosis and treatment of patients with Klinefelter syndrome. Assisted reproductive technology is essential for infertility treatment.

Published

2022-05-10

Issue

Vol. 87 No. 2 (2022): Česká gynekologie

Section

Gynecology and Obstetrics

Categories