Concurrent acute megakaryoblastic leukemia and mediastinal germ cell tumor: case report and literature review

Acute megykaryoblastic leukemia and mediastinal germ cell tumor

Authors

  • Eva Mnacakanová Hemato-onkologická klinika FNOL
  • Tomáš Szotkowski Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Helena Urbánková Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Milena Holzerová Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Martina Divoká Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Zuzana Pikalová Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Anna Lapčíková Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Jiří Ehrmann Ústav klinické a molekulární patologie Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Clinical and Molecular Pathology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Jan Soukup Ústav patologie a molekulární medicíny 2. Lékařské fakulty Univerzity Karlovy a Fakultní nemocnice v Motole , Department of Pathology and Molecular Medicine, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital ,
  • Filip Čtvrtlík Radiologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Radiology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Radim Formánek Klinika nukleární medicíny Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Nuclear Medicine, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Edgar Faber Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,
  • Tomáš Papajík Hemato-onkologická klinika Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc , Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc ,

Keywords:

acute megakaryoblastic leukemia, mediastinal germ cell tumor

Abstract

The occurrence of hematological malignancies associated with germ cell tumors was described for the first time in literature in 1985. Since then more than 60 cases were published, in most cases the involved tumors were mediastinal germ cell tumor and acute megakaryoblastic leukemia. Germ cell tumors as well as acute megakaryoblastic leukemias are rare neoplasms both of which are characterized by poor prognosis when concurrent with a dismal median survival being six months from the date of diagnosis. Recent data suggest a clonal relationship between these two neoplasms when occurring concurrently due to the common presence of isochromosome 12p and mutations of TP53, NRAS and PTEN in both units. Our case report presents a rare case of concurrent mediastinal germ cell tumor and acute megakaryoblastic leukemia treated at our center with review of literature focusing on molecular changes in these neoplasms.

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Published

2022-03-15

Issue

Vol. 28 No. 1 (2022): Transfuze a hematologie dnes

Section

Haematology

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